# Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma

> **NCT05678348** · EARLY_PHASE1 · COMPLETED · sponsor: **Washington University School of Medicine** · enrollment: 22 (actual)

## Conditions studied

- Head and Neck Cancer
- Cancer of the Head and Neck

## Interventions

- **DRUG:** Pyrimethamine

## Key facts

- **NCT ID:** NCT05678348
- **Lead sponsor:** Washington University School of Medicine
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-08-03
- **Primary completion:** 2025-07-11
- **Final completion:** 2025-08-04
- **Target enrollment:** 22 (ACTUAL)
- **Last updated:** 2025-08-17

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05678348

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05678348, "Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT05678348. Licensed CC0.

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