# Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

> **NCT05686798** · PHASE1 · RECRUITING · sponsor: **Henry Ford Health System** · enrollment: 18 (estimated)

## Conditions studied

- Malignant Glioma of Brain
- Astrocytoma
- Malignant Astrocytoma
- Brain Tumor
- Glioma
- Brain Cancer
- Glioblastoma
- Glioblastoma Multiforme
- GBM

## Interventions

- **BIOLOGICAL:** Ad5-yCD/mutTKSR39rep-ADP adenovirus and fractionated stereotactic radiosurgery (fSRS)

## Key facts

- **NCT ID:** NCT05686798
- **Lead sponsor:** Henry Ford Health System
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-11-29
- **Primary completion:** 2027-01
- **Final completion:** 2027-12
- **Target enrollment:** 18 (ESTIMATED)
- **Last updated:** 2025-12-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05686798

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05686798, "Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.". Retrieved via AI Analytics 2026-07-05 from https://api.ai-analytics.org/clinical/NCT05686798. Licensed CC0.

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