# Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML

> **NCT05703126** · NA · RECRUITING · sponsor: **Samara State Medical University** · enrollment: 100 (estimated)

## Conditions studied

- Acute Myeloid Leukemia, Adult
- Cardiotoxicity
- Endothelial Dysfunction

## Interventions

- **DIAGNOSTIC_TEST:** History taking
- **DIAGNOSTIC_TEST:** Anthropometry
- **DIAGNOSTIC_TEST:** Complete blood count
- **DIAGNOSTIC_TEST:** Biochemical blood test
- **DIAGNOSTIC_TEST:** Coagulogram
- **DIAGNOSTIC_TEST:** Immunoenzymatic analysis of the level of endothelin-1, asymmetric dimethylarginine
- **DIAGNOSTIC_TEST:** Stress echocardiography with the definition of global longitudinal deformation of the myocardium
- **DIAGNOSTIC_TEST:** Triplex scanning of neck vessels
- **DIAGNOSTIC_TEST:** Electrocardiography
- **DIAGNOSTIC_TEST:** Ultrasound of the abdominal cavity (with calculation of the area of the spleen) and lymph nodes
- **DIAGNOSTIC_TEST:** Cytogenetic examination of the bone marrow to determine genetic abnormalities.
- **DIAGNOSTIC_TEST:** Cytological examination of bone marrow cells with cytochemical examination
- **DIAGNOSTIC_TEST:** Immunophenotypic examination of the bone marrow by flow cytometry
- **DIAGNOSTIC_TEST:** Determination of the presence of a FLT3 mutation using the PCR Method
- **DIAGNOSTIC_TEST:** laser Doppler flowmetry

## Key facts

- **NCT ID:** NCT05703126
- **Lead sponsor:** Samara State Medical University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-12-01
- **Primary completion:** 2025-01-01
- **Final completion:** 2025-08-03
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2024-11-05


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05703126

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05703126, "Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT05703126. Licensed CC0.

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