# Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED

> **NCT05727878** · PHASE2 · TERMINATED · sponsor: **Combangio, Inc** · enrollment: 103 (actual)

## Conditions studied

- Persistent Corneal Epithelial Defect

## Interventions

- **DRUG:** KPI-012
- **DRUG:** KPI-012 Vehicle

## Key facts

- **NCT ID:** NCT05727878
- **Lead sponsor:** Combangio, Inc
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2023-02-07
- **Primary completion:** 2025-09-29
- **Final completion:** 2025-10-19
- **Target enrollment:** 103 (ACTUAL)
- **Why stopped:** Lack of efficacy
- **Last updated:** 2025-10-22

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05727878

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05727878, "Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT05727878. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*