CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors
Conditions
- Advanced Biliary Tract Carcinoma
- Advanced Colorectal Carcinoma
- Advanced Gastroesophageal Junction Adenocarcinoma
- Advanced Lung Adenocarcinoma
- Advanced Malignant Solid Neoplasm
- Advanced Ovarian Carcinoma
- Advanced Pancreatic Carcinoma
- Advanced Urothelial Carcinoma
- Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
- Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
- Metastatic Biliary Tract Carcinoma
- Metastatic Colorectal Carcinoma
- Metastatic Gastroesophageal Junction Adenocarcinoma
- Metastatic Lung Adenocarcinoma
- Metastatic Ovarian Carcinoma
- Metastatic Pancreatic Carcinoma
- Metastatic Urothelial Carcinoma
- Refractory Biliary Tract Carcinoma
- Refractory Colorectal Carcinoma
- Refractory Gastroesophageal Junction Adenocarcinoma
- Refractory Lung Adenocarcinoma
- Refractory Ovarian Carcinoma
- Refractory Pancreatic Carcinoma
- Refractory Urothelial Carcinoma
- Stage II Pancreatic Cancer AJCC v8
- Stage III Colorectal Cancer AJCC v8
- Stage III Lung Cancer AJCC v8
- Stage III Ovarian Cancer AJCC v8
- Stage III Pancreatic Cancer AJCC v8
- Stage IV Colorectal Cancer AJCC v8
- Stage IV Lung Cancer AJCC v8
- Stage IV Ovarian Cancer AJCC v8
- Stage IV Pancreatic Cancer AJCC v8
Interventions
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Computed Tomography
- DRUG: Devimistat
- DRUG: Fluorouracil
- DRUG: Gemcitabine Hydrochloride
- DRUG: Hydroxychloroquine
- PROCEDURE: Magnetic Resonance Imaging
Sponsor
Northwestern University
Collaborators