Effect of Alpelisib in Healthy Volunteers

Conditions

• Insulin Resistance
• Hyperinsulinemia
• Dyslipidemias

Interventions

• DRUG: Alpelisib 150 mg [Piqray], 2 overencapsulated tablets (total: 300 mg)
• DRUG: Placebo (microcrystalline cellulose), 2 capsules
• DEVICE: FreeStyle Libre Pro
• DIAGNOSTIC_TEST: Oral glucose tolerance test (OGTT) with Trutol glucose beverage
• DIETARY_SUPPLEMENT: BOOST Plus nutritional beverage

Sponsor

Columbia University