# Efficacy, Safety, and Tolerability of Higher Doses Estrogen Therapy in Women With Premature Ovarian Insufficiency

> **NCT05737329** · PHASE1,PHASE2 · UNKNOWN · sponsor: **Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare** · enrollment: 80 (actual)

## Conditions studied

- Primary Ovarian Insufficiency

## Interventions

- **DRUG:** Transdermal estradiol gel 0.1% 1.5mg/ day
- **DRUG:** Transdermal estradiol gel 0.1% 2.0mg/ day

## Key facts

- **NCT ID:** NCT05737329
- **Lead sponsor:** Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
- **Sponsor class:** OTHER_GOV
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2019-03-01
- **Primary completion:** 2023-04
- **Final completion:** 2023-04
- **Target enrollment:** 80 (ACTUAL)
- **Last updated:** 2023-02-28


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05737329

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05737329, "Efficacy, Safety, and Tolerability of Higher Doses Estrogen Therapy in Women With Premature Ovarian Insufficiency". Retrieved via AI Analytics 2026-06-22 from https://api.ai-analytics.org/clinical/NCT05737329. Licensed CC0.

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