# A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy

> **NCT05737784** · PHASE1,PHASE2 · RECRUITING · sponsor: **Praxis Precision Medicines** · enrollment: 60 (estimated)

## Conditions studied

- SCN2A-DEE
- Epilepsy

## Interventions

- **DRUG:** PRAX-222 - Initial Dose
- **DRUG:** PRAX-222 - Initial Ascending Doses
- **DRUG:** PRAX-222 - Optional Ascending Doses
- **DRUG:** PRAX-222 - Fixed Doses
- **PROCEDURE:** Placebo

## Key facts

- **NCT ID:** NCT05737784
- **Lead sponsor:** Praxis Precision Medicines
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-04-13
- **Primary completion:** 2025-08
- **Final completion:** 2027-09
- **Target enrollment:** 60 (ESTIMATED)
- **Last updated:** 2025-08-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05737784

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05737784, "A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT05737784. Licensed CC0.

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