HEM-iSMART-A: Decitabine / Venetoclax and Navitoclax in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

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Conditions

• Acute Lymphoblastic Leukemia, in Relapse
• Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
• Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent
• Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
• Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Interventions

• DRUG: Decitabine
• DRUG: Venetoclax
• DRUG: Navitoclax
• DRUG: intrathecal chemotherapy

Sponsor

Princess Maxima Center for Pediatric Oncology

Collaborators

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