# A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox

> **NCT05740982** · PHASE2 · COMPLETED · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 450 (actual)

## Conditions studied

- Monkeypox

## Interventions

- **BIOLOGICAL:** JYNNEOS

## Key facts

- **NCT ID:** NCT05740982
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-03-22
- **Primary completion:** 2024-08-28
- **Final completion:** 2024-08-28
- **Target enrollment:** 450 (ACTUAL)
- **Last updated:** 2026-03-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05740982

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05740982, "A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT05740982. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*