# Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers

> **NCT05741060** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Akira Sekikawa** · enrollment: 369 (actual)

## Conditions studied

- Arterial Stiffness
- White Matter Lesions
- Cognitive Decline

## Interventions

- **DRUG:** S-equol
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT05741060
- **Lead sponsor:** Akira Sekikawa
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-06-29
- **Primary completion:** 2026-10-31
- **Final completion:** 2027-01-30
- **Target enrollment:** 369 (ACTUAL)
- **Last updated:** 2025-09-29

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05741060

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05741060, "Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT05741060. Licensed CC0.

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