# Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT

> **NCT05745987** · PHASE4 · RECRUITING · sponsor: **McMaster University** · enrollment: 3000 (estimated)

## Conditions studied

- Monkeypox

## Interventions

- **DRUG:** Bavarian Nordic smallpox vaccine
- **DRUG:** Typhoid VI Polysaccharide Vaccine Injectable Solution

## Key facts

- **NCT ID:** NCT05745987
- **Lead sponsor:** McMaster University
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-09-17
- **Primary completion:** 2026-06-01
- **Final completion:** 2026-12-01
- **Target enrollment:** 3000 (ESTIMATED)
- **Last updated:** 2025-07-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05745987

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05745987, "Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT05745987. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*