HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies

Conditions

• Acute Lymphoblastic Leukemia
• Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
• Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent
• Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
• Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Interventions

• DRUG: Dasatinib
• DRUG: Venetoclax
• DRUG: Dexamethasone
• DRUG: Cyclophosphamide
• DRUG: Cytarabine
• DRUG: intrathecal chemotherapy

Sponsor

Princess Maxima Center for Pediatric Oncology

Collaborators

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