# Mechanisms of Diuretic Resistance in Heart Failure, Aim 2

> **NCT05753059** · PHASE1 · RECRUITING · sponsor: **Yale University** · enrollment: 50 (estimated)

## Conditions studied

- Heart Failure

## Interventions

- **DRUG:** Placebo
- **DRUG:** Amiloride
- **DRUG:** Bendroflumethiazide

## Key facts

- **NCT ID:** NCT05753059
- **Lead sponsor:** Yale University
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-08-10
- **Primary completion:** 2027-06
- **Final completion:** 2027-06
- **Target enrollment:** 50 (ESTIMATED)
- **Last updated:** 2025-06-18

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05753059

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05753059, "Mechanisms of Diuretic Resistance in Heart Failure, Aim 2". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT05753059. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*