# Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis

> **NCT05759845** · PHASE4 · UNKNOWN · sponsor: **Dr. Reaz Mahmud** · enrollment: 150 (estimated)

## Conditions studied

- Migraine

## Interventions

- **DRUG:** Topiramate 25Mg Tab
- **DRUG:** Amitriptyline 25 Mg Oral Tablet
- **DRUG:** topiramate 25mg plus amitriptyline 25mg

## Key facts

- **NCT ID:** NCT05759845
- **Lead sponsor:** Dr. Reaz Mahmud
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2022-08-22
- **Primary completion:** 2023-02-28
- **Final completion:** 2023-05-31
- **Target enrollment:** 150 (ESTIMATED)
- **Last updated:** 2023-03-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05759845

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05759845, "Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT05759845. Licensed CC0.

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