# A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

> **NCT05761171** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 78 (estimated)

## Conditions studied

- Recurrent Acute Leukemia of Ambiguous Lineage
- Recurrent Acute Lymphoblastic Leukemia
- Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage
- Recurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged
- Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia
- Recurrent Mixed Phenotype Acute Leukemia
- Refractory Acute Leukemia of Ambiguous Lineage
- Refractory Acute Lymphoblastic Leukemia
- Refractory Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous Lineage
- Refractory Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-Rearranged
- Refractory Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute Leukemia
- Refractory Mixed Phenotype Acute Leukemia

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **DRUG:** Calaspargase Pegol
- **DRUG:** Cytarabine
- **PROCEDURE:** Echocardiography Test
- **PROCEDURE:** Electrocardiogram
- **DRUG:** Fludarabine Phosphate
- **DRUG:** Hydrocortisone Sodium Succinate
- **PROCEDURE:** Lumbar Puncture
- **DRUG:** Methotrexate
- **PROCEDURE:** Multigated Acquisition Scan
- **DRUG:** Prednisolone
- **DRUG:** Prednisone
- **DRUG:** Revumenib
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT05761171
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2024-01-08
- **Primary completion:** 2027-12-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 78 (ESTIMATED)
- **Last updated:** 2026-04-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05761171

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05761171, "A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia". Retrieved via AI Analytics 2026-06-22 from https://api.ai-analytics.org/clinical/NCT05761171. Licensed CC0.

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