# Early or Delayed Intervention of Brain Radiotherapy Combined With Almonertinib in EGFR Mutated NSCLC With Brain Metastases

> **NCT05768490** · PHASE3 · RECRUITING · sponsor: **Sun Yat-sen University** · enrollment: 232 (estimated)

## Conditions studied

- Brain Metastases
- Radiotherapy
- EGFR Activating Mutation

## Interventions

- **RADIATION:** brain radiotherapy
- **DRUG:** Almonertinib

## Key facts

- **NCT ID:** NCT05768490
- **Lead sponsor:** Sun Yat-sen University
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-03-15
- **Primary completion:** 2028-12-31
- **Final completion:** 2029-12-31
- **Target enrollment:** 232 (ESTIMATED)
- **Last updated:** 2023-03-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05768490

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05768490, "Early or Delayed Intervention of Brain Radiotherapy Combined With Almonertinib in EGFR Mutated NSCLC With Brain Metastases". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT05768490. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*