# Trial Of PreoperAtive Radiation (TOPAz): A Randomized Trial Comparing Hypofractionated Versus Conventionally Fractionated Preoperative Radiation Followed by Mastectomy With Immediate Autologous Breast Reconstruction With Integrated Nanomechanical Biomarker Evaluation

> **NCT05774678** · PHASE3 · RECRUITING · sponsor: **M.D. Anderson Cancer Center** · enrollment: 126 (estimated)

## Conditions studied

- Breast Cancer

## Interventions

- **RADIATION:** Group 1 (preoperative radiation hypofractionated)
- **OTHER:** Group 2 (preoperative radiation conventionally fractionated)

## Key facts

- **NCT ID:** NCT05774678
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-04-05
- **Primary completion:** 2026-11-01
- **Final completion:** 2028-11-01
- **Target enrollment:** 126 (ESTIMATED)
- **Last updated:** 2025-12-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05774678

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05774678, "Trial Of PreoperAtive Radiation (TOPAz): A Randomized Trial Comparing Hypofractionated Versus Conventionally Fractionated Preoperative Radiation Followed by Mastectomy With Immediate Autologous Breast Reconstruction With Integrated Nanomechanical Biomarker Evaluation". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05774678. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*