# Klotho and Mineral Bone Density in Systemic Sclerosis

> **NCT05777954** · — · COMPLETED · sponsor: **Fondazione Policlinico Universitario Agostino Gemelli IRCCS** · enrollment: 126 (actual)

## Conditions studied

- Systemic Sclerosis

## Interventions

- **OTHER:** Possible Klotho effects on SSc clinical conditions, namely skeletal, fibrotic and microangiopathic damage
- **OTHER:** Evalution in healthy patients of bone mineral density, Klotho level and key bone-related cytokines

## Key facts

- **NCT ID:** NCT05777954
- **Lead sponsor:** Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** COMPLETED
- **Start date:** 2022-03-21
- **Primary completion:** 2024-04-30
- **Final completion:** 2024-04-30
- **Target enrollment:** 126 (ACTUAL)
- **Last updated:** 2025-03-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05777954

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05777954, "Klotho and Mineral Bone Density in Systemic Sclerosis". Retrieved via AI Analytics 2026-07-05 from https://api.ai-analytics.org/clinical/NCT05777954. Licensed CC0.

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