# Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding NP-GT8 and IL-12, With or Without a TLR-agonist-Adjuvanted HIV Env Trimer 4571 Boost, in Adults Without HIV

> **NCT05781542** · PHASE1 · COMPLETED · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 46 (actual)

## Conditions studied

- HIV Infections

## Interventions

- **BIOLOGICAL:** sD-NP-GT8 DNA
- **BIOLOGICAL:** sD-NP-GT8 DNA
- **BIOLOGICAL:** IL-12 DNA
- **BIOLOGICAL:** IL-12 DNA
- **BIOLOGICAL:** Trimer 4571
- **BIOLOGICAL:** 3M-052-AF
- **DRUG:** Alum

## Key facts

- **NCT ID:** NCT05781542
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-04-10
- **Primary completion:** 2024-10-02
- **Final completion:** 2025-04-14
- **Target enrollment:** 46 (ACTUAL)
- **Last updated:** 2025-11-14

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05781542

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05781542, "Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding NP-GT8 and IL-12, With or Without a TLR-agonist-Adjuvanted HIV Env Trimer 4571 Boost, in Adults Without HIV". Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/clinical/NCT05781542. Licensed CC0.

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