# Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK

> **NCT05789173** · EARLY_PHASE1 · RECRUITING · sponsor: **Indiana University** · enrollment: 60 (estimated)

## Conditions studied

- Drug-Drug Interaction

## Interventions

- **DRUG:** Methadone and Tizanidine
- **DRUG:** Efavirenz, Methadone and Tizanidine

## Key facts

- **NCT ID:** NCT05789173
- **Lead sponsor:** Indiana University
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-10-06
- **Primary completion:** 2026-04-15
- **Final completion:** 2026-04-15
- **Target enrollment:** 60 (ESTIMATED)
- **Last updated:** 2026-02-12

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05789173

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05789173, "Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK". Retrieved via AI Analytics 2026-07-19 from https://api.ai-analytics.org/clinical/NCT05789173. Licensed CC0.

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