# Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

> **NCT05800405** · EARLY_PHASE1 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 9 (estimated)

## Conditions studied

- Recurrent Diffuse Large B-Cell Lymphoma
- Refractory Diffuse Large B-Cell Lymphoma

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **BIOLOGICAL:** Chimeric Antigen Receptor T-Cell Therapy
- **PROCEDURE:** Computed Tomography
- **RADIATION:** External Beam Radiation Therapy
- **PROCEDURE:** Leukapheresis
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Positron Emission Tomography

## Key facts

- **NCT ID:** NCT05800405
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-07-20
- **Primary completion:** 2027-01-04
- **Final completion:** 2027-01-04
- **Target enrollment:** 9 (ESTIMATED)
- **Last updated:** 2026-02-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05800405

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05800405, "Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma". Retrieved via AI Analytics 2026-07-08 from https://api.ai-analytics.org/clinical/NCT05800405. Licensed CC0.

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