# PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer

> **NCT05805371** · PHASE1 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 21 (estimated)

## Conditions studied

- Castration-Resistant Prostate Carcinoma
- Metastatic Prostate Carcinoma
- Stage IVB Prostate Cancer AJCC v8

## Interventions

- **BIOLOGICAL:** Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes
- **PROCEDURE:** Biopsy
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Scan
- **PROCEDURE:** Computed Tomography
- **RADIATION:** External Beam Radiation Therapy
- **PROCEDURE:** Leukapheresis
- **PROCEDURE:** Lymphodepletion Therapy

## Key facts

- **NCT ID:** NCT05805371
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-07-19
- **Primary completion:** 2028-11-11
- **Final completion:** 2028-11-11
- **Target enrollment:** 21 (ESTIMATED)
- **Last updated:** 2025-11-19

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05805371

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05805371, "PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer". Retrieved via AI Analytics 2026-07-19 from https://api.ai-analytics.org/clinical/NCT05805371. Licensed CC0.

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