# Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

> **NCT05821959** · PHASE1,PHASE2 · RECRUITING · sponsor: **Akouos, Inc.** · enrollment: 22 (estimated)

## Conditions studied

- Sensorineural Hearing Loss, Bilateral

## Interventions

- **COMBINATION_PRODUCT:** AAVAnc80-hOTOF via Akouos Delivery Device
- **COMBINATION_PRODUCT:** AAVAnc80-hOTOF via Akouos Delivery Device and Precision Delivery Mechanism

## Key facts

- **NCT ID:** NCT05821959
- **Lead sponsor:** Akouos, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-09-15
- **Primary completion:** 2028-10
- **Final completion:** 2028-10
- **Target enrollment:** 22 (ESTIMATED)
- **Last updated:** 2026-03-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05821959

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05821959, "Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss". Retrieved via AI Analytics 2026-07-28 from https://api.ai-analytics.org/clinical/NCT05821959. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*