# CPL-01 in the Management of Postoperative Pain After Bunionectomy

> **NCT05831449** · PHASE3 · COMPLETED · sponsor: **Cali Pharmaceuticals LLC** · enrollment: 616 (actual)

## Conditions studied

- Bunion
- Post-operative Pain

## Interventions

- **DRUG:** Local anesthetic injection of CPL-01
- **DRUG:** Naropin, 0.5% Injectable Solution
- **DRUG:** Placebo
- **DRUG:** Morphine rescue medication
- **DRUG:** Acetaminophen rescue medication
- **DRUG:** Oxycodone rescue medication
- **PROCEDURE:** Bunionectomy

## Key facts

- **NCT ID:** NCT05831449
- **Lead sponsor:** Cali Pharmaceuticals LLC
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-05-22
- **Primary completion:** 2025-09-25
- **Final completion:** 2025-10-06
- **Target enrollment:** 616 (ACTUAL)
- **Last updated:** 2026-04-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05831449

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05831449, "CPL-01 in the Management of Postoperative Pain After Bunionectomy". Retrieved via AI Analytics 2026-07-18 from https://api.ai-analytics.org/clinical/NCT05831449. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*