# A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain

> **NCT05838742** · PHASE2 · TERMINATED · sponsor: **GlaxoSmithKline** · enrollment: 314 (actual)

## Conditions studied

- Pain
- Osteoarthritis, Knee

## Interventions

- **DRUG:** GSK3858279
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT05838742
- **Lead sponsor:** GlaxoSmithKline
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2023-09-13
- **Primary completion:** 2024-08-12
- **Final completion:** 2024-12-03
- **Target enrollment:** 314 (ACTUAL)
- **Why stopped:** The study met futility criteria at pre-planned interim analysis, showing no clinical efficacy of the investigational drug. Based on the lack of efficacy at the interim data review, the sponsor decided to terminate the study.
- **Last updated:** 2025-11-10


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05838742

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05838742, "A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain". Retrieved via AI Analytics 2026-07-19 from https://api.ai-analytics.org/clinical/NCT05838742. Licensed CC0.

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