# A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer

> **NCT05846867** · PHASE1,PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Akeso** · enrollment: 170 (estimated)

## Conditions studied

- Colorectal Cancer

## Interventions

- **DRUG:** AK119
- **DRUG:** AK112
- **DRUG:** Oxaliplatin
- **DRUG:** Irinotecan
- **DRUG:** Calcium folinate
- **DRUG:** Fluorouracil

## Key facts

- **NCT ID:** NCT05846867
- **Lead sponsor:** Akeso
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-05-08
- **Primary completion:** 2026-05-08
- **Final completion:** 2026-08-11
- **Target enrollment:** 170 (ESTIMATED)
- **Last updated:** 2026-03-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05846867

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05846867, "A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer". Retrieved via AI Analytics 2026-07-05 from https://api.ai-analytics.org/clinical/NCT05846867. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*