# Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases

> **NCT05879419** · PHASE4 · ACTIVE_NOT_RECRUITING · sponsor: **University of Sao Paulo General Hospital** · enrollment: 2005 (estimated)

## Conditions studied

- Rheumatoid Arthritis
- Spondylitis, Ankylosing
- Spondyloarthritis
- Systemic Lupus Erythematosus
- Sjogren's Syndrome
- Systemic Sclerosis
- Idiopathic Inflammatory Myopathies
- Vasculitis, Systemic
- Juvenile Idiopathic Arthritis
- Dermatomyositis, Juvenile
- Behçet Disease

## Interventions

- **BIOLOGICAL:** Recombinant Herpes Zoster Vaccine (RZV)
- **OTHER:** MTX Discontinuation
- **OTHER:** MMF Discontinuation
- **OTHER:** Placebo
- **OTHER:** MTX maintain
- **OTHER:** MMF maintain

## Key facts

- **NCT ID:** NCT05879419
- **Lead sponsor:** University of Sao Paulo General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-05-23
- **Primary completion:** 2025-12-01
- **Final completion:** 2032-06-30
- **Target enrollment:** 2005 (ESTIMATED)
- **Last updated:** 2026-05-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05879419

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05879419, "Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT05879419. Licensed CC0.

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