A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction

Conditions

• Heart Failure With Preserved Ejection Fraction
• Heart Failure, Diastolic
• Diabetes Mellitus, Type 2
• Diabetes Mellitus Type 2 in Obese
• Obesity Adult Onset

Interventions

• DRUG: Low calorie meal replacement plan
• DIAGNOSTIC_TEST: Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy
• DIAGNOSTIC_TEST: Transthoracic echocardiography
• DIAGNOSTIC_TEST: Blood test
• DIAGNOSTIC_TEST: Electrocardiogram
• DIAGNOSTIC_TEST: Accelerometery
• DIAGNOSTIC_TEST: 6 minute walk test (6MWT)
• DIAGNOSTIC_TEST: Skeletal muscle strength using handgrip strength and quadriceps (Cybex dynamometer)
• OTHER: Assessment of quality of life and heart failure symptoms
• OTHER: Assessment of sarcopenia
• OTHER: Assessment of frailty
• OTHER: Qualitative interview

Sponsor

University of Leicester

Collaborators

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