# Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors

> **NCT05887882** · PHASE1 · SUSPENDED · sponsor: **Sabine Mueller, MD, PhD** · enrollment: 24 (estimated)

## Conditions studied

- Pediatric Brain Tumor
- Recurrent Pediatric Brain Tumor
- Pediatric Neoplasm

## Interventions

- **BIOLOGICAL:** Universal Donor (UD) Transforming growth factor beta imprinting (TGFβi) Natural Killer (NK) Cells
- **PROCEDURE:** Implantation
- **PROCEDURE:** Magnetic Resonance Imaging (MRI)
- **OTHER:** Quality-of-Life Assessment

## Key facts

- **NCT ID:** NCT05887882
- **Lead sponsor:** Sabine Mueller, MD, PhD
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** SUSPENDED
- **Start date:** 2024-05-31
- **Primary completion:** 2027-12-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 24 (ESTIMATED)
- **Why stopped:** Enrollment on hold while reviewing a SAE.
- **Last updated:** 2026-04-24

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05887882

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05887882, "Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors". Retrieved via AI Analytics 2026-06-05 from https://api.ai-analytics.org/clinical/NCT05887882. Licensed CC0.

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