# Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV-1 Envelope Trimers Followed by Boost With mRNA Lipid Nanoparticles Encoding a Native-like HIV-1 Envelope Trimer in Adults Without HIV

> **NCT05903339** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 36 (actual)

## Conditions studied

- Hiv

## Interventions

- **DRUG:** V3G CH848 Pr-NP1 60mcg
- **DRUG:** 3M-052-AF 5mcg
- **DRUG:** Alum 500 mcg
- **DRUG:** V3G CH848 mRNA-Tr2 50mcg
- **DRUG:** ACU-026-001-1 2.0mg
- **DRUG:** V3G CH848 Pr-NP1 100mcg

## Key facts

- **NCT ID:** NCT05903339
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-08-29
- **Primary completion:** 2026-12-18
- **Final completion:** 2026-12-18
- **Target enrollment:** 36 (ACTUAL)
- **Last updated:** 2026-04-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05903339

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05903339, "Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV-1 Envelope Trimers Followed by Boost With mRNA Lipid Nanoparticles Encoding a Native-like HIV-1 Envelope Trimer in Adults Without HIV". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT05903339. Licensed CC0.

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