# Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects

> **NCT05906563** · PHASE2 · UNKNOWN · sponsor: **Amira ragab** · enrollment: 52 (estimated)

## Conditions studied

- Bone Loss in Jaw

## Interventions

- **DRUG:** Melatonin gel
- **DRUG:** Metformin and melatonin gel
- **DRUG:** placebo gel
- **PROCEDURE:** scaling and root planning

## Key facts

- **NCT ID:** NCT05906563
- **Lead sponsor:** Amira ragab
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2022-12-14
- **Primary completion:** 2024-05
- **Final completion:** 2024-06
- **Target enrollment:** 52 (ESTIMATED)
- **Last updated:** 2023-06-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05906563

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05906563, "Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT05906563. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*