# Comparison of Histamine and Local Heating for Evoking the Axon-reflex Flare Response in Diabetes

> **NCT05921097** · — · COMPLETED · sponsor: **Aalborg University Hospital** · enrollment: 40 (actual)

## Conditions studied

- Diabetes
- Diabetes Mellitus, Type 1
- Diabetic Neuropathy Peripheral
- Small Fiber Neuropathy

## Interventions

- **DIAGNOSTIC_TEST:** Histamin-induced axon-reflex flare response
- **DIAGNOSTIC_TEST:** Local heating-induced axon-reflex flare response
- **DIAGNOSTIC_TEST:** 2-point discrimination tasks
- **DIAGNOSTIC_TEST:** NC-Stat DPNCheck
- **DIAGNOSTIC_TEST:** QST
- **DIAGNOSTIC_TEST:** Biothesiometry

## Key facts

- **NCT ID:** NCT05921097
- **Lead sponsor:** Aalborg University Hospital
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** COMPLETED
- **Start date:** 2023-06-17
- **Primary completion:** 2024-06-17
- **Final completion:** 2024-07-29
- **Target enrollment:** 40 (ACTUAL)
- **Last updated:** 2024-07-30

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05921097

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05921097, "Comparison of Histamine and Local Heating for Evoking the Axon-reflex Flare Response in Diabetes". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05921097. Licensed CC0.

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