# A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

> **NCT05926765** · PHASE2 · RECRUITING · sponsor: **MeiraGTx, LLC** · enrollment: 276 (estimated)

## Conditions studied

- Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

## Interventions

- **GENETIC:** AAV2-hAQP1 Concentration 1
- **GENETIC:** AAV2-hAQP1 Concentration 2
- **OTHER:** Placebo
- **GENETIC:** AAV2-hAQP1 Concentration 3
- **GENETIC:** AAV2-hAQP1 Concentration 4

## Key facts

- **NCT ID:** NCT05926765
- **Lead sponsor:** MeiraGTx, LLC
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-06-13
- **Primary completion:** 2026-12
- **Final completion:** 2026-12
- **Target enrollment:** 276 (ESTIMATED)
- **Last updated:** 2026-02-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05926765

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05926765, "A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT05926765. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*