# Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma

> **NCT05929495** · PHASE2 · RECRUITING · sponsor: **University of Milano Bicocca** · enrollment: 25 (estimated)

## Conditions studied

- Glioblastoma, IDH-wildtype
- Metformin
- Malignancies

## Interventions

- **DRUG:** Metformin

## Key facts

- **NCT ID:** NCT05929495
- **Lead sponsor:** University of Milano Bicocca
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-02-12
- **Primary completion:** 2026-01-01
- **Final completion:** 2026-01-01
- **Target enrollment:** 25 (ESTIMATED)
- **Last updated:** 2025-07-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05929495

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05929495, "Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT05929495. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*