# Guanfacine Extended-release for Adolescents With Cannabis Use

> **NCT05957848** · PHASE2 · RECRUITING · sponsor: **Orygen** · enrollment: 100 (estimated)

## Conditions studied

- Cannabis Use Disorder

## Interventions

- **DRUG:** Guanfacine Extended Release Oral Tablet
- **BEHAVIORAL:** Residential withdrawal
- **BEHAVIORAL:** Engagement with alcohol and other drug services
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT05957848
- **Lead sponsor:** Orygen
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-07-27
- **Primary completion:** 2025-12-31
- **Final completion:** 2026-06-30
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2025-07-31

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05957848

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05957848, "Guanfacine Extended-release for Adolescents With Cannabis Use". Retrieved via AI Analytics 2026-07-06 from https://api.ai-analytics.org/clinical/NCT05957848. Licensed CC0.

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