# Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (OPENS-3)

> **NCT05965687** · PHASE3 · UNKNOWN · sponsor: **Ji Xunming,MD,PhD** · enrollment: 1230 (estimated)

## Conditions studied

- Acute Ischemic Stroke

## Interventions

- **PROCEDURE:** Normobaric Hyperoxia
- **PROCEDURE:** Nasal oxygen
- **DRUG:** Intravenous thrombolysis(rt-PA)

## Key facts

- **NCT ID:** NCT05965687
- **Lead sponsor:** Ji Xunming,MD,PhD
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2023-08-17
- **Primary completion:** 2024-08-30
- **Final completion:** 2024-10-30
- **Target enrollment:** 1230 (ESTIMATED)
- **Last updated:** 2024-03-28

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05965687

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05965687, "Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (OPENS-3)". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT05965687. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*