# A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors

> **NCT05973487** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **TScan Therapeutics, Inc.** · enrollment: 840 (estimated)

## Conditions studied

- Head and Neck Cancer
- Cervical Cancer
- Non-small Cell Carcinoma
- Melanoma
- Ovarian Cancer
- Anogenital Cancers
- HPV - Anogenital Human Papilloma Virus Infection
- HPV-Related Cervical Carcinoma
- HPV-Related Carcinoma
- HPV-Related Squamous Cell Carcinoma
- HPV-Related Malignancy
- HPV-Related Adenocarcinoma
- HPV Positive Oropharyngeal Squamous Cell Carcinoma
- HPV-Related Adenosquamous Carcinoma
- HPV-Associated Vaginal Adenocarcinoma
- HPV-Related Endocervical Adenocarcinoma
- HPV-Related Anal Squamous Cell Carcinoma
- HPV-Related Verrucous Carcinoma
- HPV-Related Penile Squamous Cell Carcinoma
- HPV-Related Vulvar Squamous Cell Carcinoma
- HPV Positive Rectal Squamous Cell Carcinoma

## Interventions

- **BIOLOGICAL:** TSC-204-A0201
- **BIOLOGICAL:** TSC-204-C0702
- **BIOLOGICAL:** TSC-200-A0201
- **BIOLOGICAL:** TSC-204-A0201 + TSC-204-C0702
- **BIOLOGICAL:** TSC-204-A0201 + TSC-200-A0201
- **BIOLOGICAL:** TSC-204-C0702 + TSC-200-A0201
- **BIOLOGICAL:** TSC-204-A0201 + TSC-203-A0201
- **BIOLOGICAL:** TSC-204-C0702 + TSC-203-A0201
- **BIOLOGICAL:** TSC-200-A0201 + TSC-203-A0201
- **BIOLOGICAL:** TSC-203-A0201
- **BIOLOGICAL:** TSC-204-A0101
- **BIOLOGICAL:** TSC-201-B0702
- **BIOLOGICAL:** TSC-204-A0201 + TSC-204-A0101
- **BIOLOGICAL:** TSC-204-A0201 + TSC-201-B0702
- **BIOLOGICAL:** TSC-204-C0702 + TSC-204-A0101
- **BIOLOGICAL:** TSC-204-C0702 + TSC-201-B0702
- **BIOLOGICAL:** TSC-200-A0201 + TSC-204-A0101
- **BIOLOGICAL:** TSC-200-A0201 + TSC-201-B0702
- **BIOLOGICAL:** TSC-203-A0201 + TSC-204-A0101
- **BIOLOGICAL:** TSC-203-A0201 + TSC-201-B0702

## Key facts

- **NCT ID:** NCT05973487
- **Lead sponsor:** TScan Therapeutics, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2024-05-06
- **Primary completion:** 2026-12-30
- **Final completion:** 2026-12-30
- **Target enrollment:** 840 (ESTIMATED)
- **Last updated:** 2025-11-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05973487

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05973487, "A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05973487. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*