# The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

> **NCT05973851** · PHASE3 · RECRUITING · sponsor: **Dr. Inge Winter** · enrollment: 418 (estimated)

## Conditions studied

- Major Depressive Disorder
- Treatment Resistant Depression

## Interventions

- **DRUG:** Esketamine Nasal Product
- **DRUG:** Ketamine Hydrochloride
- **DRUG:** Esketamine hydrochloride
- **DRUG:** Second-line Antidepressants

## Key facts

- **NCT ID:** NCT05973851
- **Lead sponsor:** Dr. Inge Winter
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-08-31
- **Primary completion:** 2028-06-30
- **Final completion:** 2028-06-30
- **Target enrollment:** 418 (ESTIMATED)
- **Last updated:** 2025-09-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05973851

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05973851, "The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05973851. Licensed CC0.

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