# Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion

> **NCT05976646** · PHASE1,PHASE2 · COMPLETED · sponsor: **Virginia Commonwealth University** · enrollment: 18 (actual)

## Conditions studied

- Addiction
- Opioid Use
- Substance Use Disorders
- Opioid Use Disorder

## Interventions

- **DRUG:** Placebo
- **DRUG:** Auvelity

## Key facts

- **NCT ID:** NCT05976646
- **Lead sponsor:** Virginia Commonwealth University
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-09-18
- **Primary completion:** 2025-07-09
- **Final completion:** 2025-07-09
- **Target enrollment:** 18 (ACTUAL)
- **Last updated:** 2026-05-06

## Collaborators

- National Institute on Drug Abuse (NIDA)

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05976646

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05976646, "Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT05976646. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*