# Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy

> **NCT05976685** · NA · RECRUITING · sponsor: **Insel Gruppe AG, University Hospital Bern** · enrollment: 482 (estimated)

## Conditions studied

- Ischemic Stroke
- Atrial Fibrillation

## Interventions

- **PROCEDURE:** Left atrial appendage Occlusion
- **DRUG:** DOAC

## Key facts

- **NCT ID:** NCT05976685
- **Lead sponsor:** Insel Gruppe AG, University Hospital Bern
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-05-01
- **Primary completion:** 2028-01-01
- **Final completion:** 2028-06-01
- **Target enrollment:** 482 (ESTIMATED)
- **Last updated:** 2026-04-28


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05976685

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05976685, "Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT05976685. Licensed CC0.

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