# Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline

> **NCT05980871** · PHASE4 · TERMINATED · sponsor: **National Taiwan University Hospital** · enrollment: 109 (actual)

## Conditions studied

- Early Syphilis

## Interventions

- **DRUG:** Doxycycline
- **DRUG:** Ceftriaxone
- **DRUG:** benzathine penicillin G

## Key facts

- **NCT ID:** NCT05980871
- **Lead sponsor:** National Taiwan University Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2023-03-10
- **Primary completion:** 2025-07-25
- **Final completion:** 2025-07-25
- **Target enrollment:** 109 (ACTUAL)
- **Why stopped:** An error of the sample size calculation occurred. A previous calculation based on a previous trial by Cao et al estimated to assign 150 participants to each group. A corrected calculation showed that 43 participants for each group is sufficient.
- **Last updated:** 2026-02-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05980871

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05980871, "Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT05980871. Licensed CC0.

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