# A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

> **NCT05986292** · PHASE2 · RECRUITING · sponsor: **Eli Lilly and Company** · enrollment: 10000 (estimated)

## Conditions studied

- Osteoarthritis, Knee
- Diabetic Neuropathic Pain
- Chronic Low-back Pain

## Interventions

- **DRUG:** LY3016859 ISA
- **DRUG:** LY3556050 ISA
- **DRUG:** LY3526318 ISA
- **DRUG:** LY3857210 ISA
- **DRUG:** Placebo Oral
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT05986292
- **Lead sponsor:** Eli Lilly and Company
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2020-01-30
- **Primary completion:** 2027-04
- **Final completion:** 2027-04
- **Target enrollment:** 10000 (ESTIMATED)
- **Last updated:** 2026-04-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05986292

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05986292, "A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05986292. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*