# Allogeneic CD6 Chimeric Antigen Receptor T Regulatory Cells (CD6-CAR Tregs) for the Treatment of Patients With Chronic Graft Versus Host Disease After Allogeneic Hematopoietic Cell Transplantation

> **NCT05993611** · PHASE1 · SUSPENDED · sponsor: **City of Hope Medical Center** · enrollment: 27 (estimated)

## Conditions studied

- Chronic Graft Versus Host Disease
- Hematologic and Lymphocytic Disorder
- Steroid Refractory Graft Versus Host Disease

## Interventions

- **PROCEDURE:** Biopsy
- **PROCEDURE:** Biospecimen Collection
- **BIOLOGICAL:** Chimeric Antigen Receptor T-Cell Therapy
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Echocardiography
- **OTHER:** Electronic Health Record Review
- **PROCEDURE:** Leukapheresis
- **PROCEDURE:** Lumbar Puncture
- **PROCEDURE:** Magnetic Resonance Imaging
- **OTHER:** Quality-of-Life Assessment
- **BIOLOGICAL:** Tafasitamab
- **PROCEDURE:** X-Ray Imaging

## Key facts

- **NCT ID:** NCT05993611
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** SUSPENDED
- **Start date:** 2024-02-19
- **Primary completion:** 2028-05-21
- **Final completion:** 2028-05-21
- **Target enrollment:** 27 (ESTIMATED)
- **Why stopped:** pending funding
- **Last updated:** 2025-11-13

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05993611

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05993611, "Allogeneic CD6 Chimeric Antigen Receptor T Regulatory Cells (CD6-CAR Tregs) for the Treatment of Patients With Chronic Graft Versus Host Disease After Allogeneic Hematopoietic Cell Transplantation". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT05993611. Licensed CC0.

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