Venetoclax-Navitoclax With Cladribine-based Salvage Therapy in Patients With Relapsed/Refractory Acute Myeloid Leukemia

NCT06007911 · clinicaltrials.gov ↗

PHASE1

Phase

WITHDRAWN

Status

OTHER

Sponsor class

Stopped Sponsor withdrew support.

Conditions

Relapsed Adult AML
Refractory AML

Interventions

DRUG: Navitoclax Dose Level -1
DRUG: Navitoclax Dose Level 0
DRUG: Navitoclax Dose Level 1
DRUG: Navitoclax Dose Level 2
DRUG: Venetoclax Dose Level -1
DRUG: Venetoclax Dose Levels 0 to 2
DRUG: Cladribine
DRUG: Cytarabine (Cladribine Low Dose Cytarabine Backbone)
DRUG: Cytarabine (CLAG-M Backbone)
DRUG: Mitoxantrone
DRUG: Granulocyte Colony-Stimulating Factor

Sponsor

Medical College of Wisconsin