# A Trial to Evaluate an HIV Envelope Trimer, N332-GT5 gp140, Adjuvanted With SMNP in Adult Participants Without HIV

> **NCT06033209** · PHASE1 · COMPLETED · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 57 (actual)

## Conditions studied

- HIV

## Interventions

- **BIOLOGICAL:** N332-GT5 gp140 (IM, Bolus)
- **BIOLOGICAL:** N332-GT5 gp140 (IM, Fractioned)
- **BIOLOGICAL:** N332-GT5 gp140 (SC, Bolus)
- **BIOLOGICAL:** N332-GT5 gp140 (SC, Fractioned)
- **BIOLOGICAL:** SMNP (IM, Bolus)
- **BIOLOGICAL:** SMNP (IM, Fractioned)
- **BIOLOGICAL:** SMNP (SC, Bolus)
- **BIOLOGICAL:** SMNP (SC, Fractioned)

## Key facts

- **NCT ID:** NCT06033209
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-11-27
- **Primary completion:** 2025-12-10
- **Final completion:** 2026-03-13
- **Target enrollment:** 57 (ACTUAL)
- **Last updated:** 2026-03-27

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06033209

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06033209, "A Trial to Evaluate an HIV Envelope Trimer, N332-GT5 gp140, Adjuvanted With SMNP in Adult Participants Without HIV". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06033209. Licensed CC0.

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