# Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder

> **NCT06058013** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Neumora Therapeutics, Inc.** · enrollment: 332 (estimated)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **DRUG:** NMRA-335140
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT06058013
- **Lead sponsor:** Neumora Therapeutics, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-12-20
- **Primary completion:** 2026-05
- **Final completion:** 2026-06
- **Target enrollment:** 332 (ESTIMATED)
- **Last updated:** 2026-04-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06058013

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06058013, "Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT06058013. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*