# CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

> **NCT06059391** · PHASE2 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 216 (estimated)

## Conditions studied

- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Chronic Lymphocytic Leukemia
- Chronic Myeloid Leukemia, BCR-ABL1 Positive
- Hematopoietic and Lymphoid System Neoplasm
- Hodgkin Lymphoma
- Myelodysplastic Syndrome
- Myelofibrosis
- Myeloproliferative Neoplasm
- Non-Hodgkin Lymphoma

## Interventions

- **PROCEDURE:** Allogeneic Hematopoietic Stem Cell Transplantation
- **PROCEDURE:** Biospecimen Collection
- **DRUG:** Granulocyte Colony-Stimulating Factor
- **DRUG:** Hematopoietic Cell Transplantation Conditioning Regimen
- **BIOLOGICAL:** Multi-peptide CMV-Modified Vaccinia Ankara Vaccine
- **PROCEDURE:** Pheresis
- **DRUG:** Placebo Administration
- **DRUG:** Stem Cell Mobilization Therapy

## Key facts

- **NCT ID:** NCT06059391
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-07-12
- **Primary completion:** 2028-01-01
- **Final completion:** 2029-01-01
- **Target enrollment:** 216 (ESTIMATED)
- **Last updated:** 2026-03-10

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06059391

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06059391, "CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06059391. Licensed CC0.

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