# Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast Cancer

> **NCT06121570** · PHASE1 · RECRUITING · sponsor: **Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University** · enrollment: 24 (estimated)

## Conditions studied

- Breast Neoplasms

## Interventions

- **PROCEDURE:** Sentinel Lymph Node Biopsy (SLNB)
- **DRUG:** Doxorubicin
- **DRUG:** Epirubicin
- **DRUG:** Cyclophosphamide
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine
- **BIOLOGICAL:** Tumor-draining lymph node-derived lymphocyte (LNL)
- **BIOLOGICAL:** Interleukin-2
- **DRUG:** Nab-paclitaxel

## Key facts

- **NCT ID:** NCT06121570
- **Lead sponsor:** Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-11-01
- **Primary completion:** 2026-08-31
- **Final completion:** 2031-08-31
- **Target enrollment:** 24 (ESTIMATED)
- **Last updated:** 2023-11-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06121570

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06121570, "Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast Cancer". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06121570. Licensed CC0.

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