# Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing

> **NCT06145308** · PHASE2 · RECRUITING · sponsor: **Peking Union Medical College** · enrollment: 39 (estimated)

## Conditions studied

- Salivary Gland Carcinoma
- Precision Therapy

## Interventions

- **DRUG:** Cohort 1 (HER2-positive, RC48-ADC)
- **DRUG:** Cohort 2 (NTRK-fusion or NTRK-mutant)
- **DRUG:** Cohort 3 (AR-positive, leuprolide + bicalutamide + abiraterone)
- **DRUG:** TROP2 ADC
- **DRUG:** TKI
- **DRUG:** Albumin-paclitaxel + platinum
- **DRUG:** Albumin-paclitaxel + carboplatin + apatinib + camrelizumab
- **DRUG:** albumin-bound paclitaxel+trastuzumab+pyrotinib
- **DRUG:** HER2,trastuzumab deruxtecan± pertuzumab
- **DRUG:** AR,AR antagonist ++ goserelin + pertuzumab + trastuzumab
- **DRUG:** AR,AR antagonist +goserelin +docetaxel
- **DRUG:** ivonescimab + investigator-choice platinum doublet+
- **DRUG:** iparomlimab + tuvonralimab
- **DRUG:** cadonilimab
- **DRUG:** CDK4/6 inhibitor+AI or fulvestrant
- **DRUG:** alpelisib+fulvestrant
- **DRUG:** PARP inhibitor
- **DRUG:** enfortumab vedotin
- **DRUG:** HER2, pyrotinib + pertuzumab/trastuzumab
- **DRUG:** vebecotutamab ±lenvatinib

## Key facts

- **NCT ID:** NCT06145308
- **Lead sponsor:** Peking Union Medical College
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-08-15
- **Primary completion:** 2028-07-10
- **Final completion:** 2028-07-10
- **Target enrollment:** 39 (ESTIMATED)
- **Last updated:** 2026-04-02

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06145308

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06145308, "Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT06145308. Licensed CC0.

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